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LATER MIGHT BE TOO LATE:
CONSIDER THE THREAT OF HEART FAILURE EARLIER IN THE T2D JOURNEY.

A quick look at a few key statistics paint a clear picture of the degree to which patients with type 2 diabetes are at an increased risk for heart failure, compared to those without T2D.1

THIS RISK OF HEART FAILURE STARTS EARLIER THAN YOU MIGHT SUSPECT IN YOUR PATIENTS WITH T2D2

For patients with T2D, heart failure is a more common first CV complication than myocardial infarction (MI) or stroke.3

CV Cohort Study Chart
50% Patients with T2D Develop Heart Failure

Up to
50%
of patients with T2D may develop heart failure2†

68% Percent People with T2D Showed Left Ventricular Dysfunction

In fact, 68% of people with T2D showed signs of left ventricular (LV) dysfunction within 5 years of a diabetes diagnosis in the absence of inducible ischemia2‡

Even patients with prediabetes show evidence of heart damage that may be associated with heart failure

YET, AMONG PATIENTS WITH T2D, THERE IS A HIGH PREVALENCE OF UNDIAGNOSED HEART FAILURE6

In one study,
28% of patients with T2D were found to have previously undiagnosed heart failure6||

*Not further specified.

According to the American Diabetes Association Standards of Medical Care in Diabetes—2019.4

Prospective, multicenter study, evaluating clinical and echocardiographic characteristics of individuals with T2D (n=386) who were determined to be free from cardiac disease. Mean duration of diabetes was 5 years; mean A1C was 7.1%. LVD comprised of the combined asymptomatic left ventricular systolic and/or diastolic dysfunction.2

§Prediabetes defined as A1C of 5.7% to 6.4%. Heart damage as measured by elevated cardiac troponin T (≥14 ng/L).5

||In a cross-sectional study to assess the prevalence of unknown heart failure in 581 patients with T2D (≥60 years).6

References +

MEASURING THE TOLL:
THE IMPACT OF HEART FAILURE IN TYPE 2 DIABETES (T2D)

With the increased risk for heart failure, patients with type 2 diabetes mellitus also face a statistically greater risk for related hospitalization1 and death.2

INCREASED RISKS FOR HOSPITALIZATION, MEDICAL COSTS, AND READMISSION

Higher Chance of Hospitalization for 33% People with T2D

Patients with T2D have a 33%
higher chance of
hospitalization for heart failure
than those without T2D1*

On average, the cost of heart failure-related hospitalization was approximately $23,0003†

Heart failure is the most frequent diagnosis associated with a 30-day readmission4

ONCE HEART FAILURE IS DIAGNOSED, THE PROGNOSIS IS GRIM

Cardiac function progressively worsens over time after acute heart failure events.5

40% People with T2D Died within 5 Years of Heart Failure

Over
40%
of patients with T2D died within
5 years of a diagnosis of heart failure

In one study, the five-year Kaplan-Meier survival estimates were significantly lower in patients who developed HF compared with those without HF.4‡

For patients with T2D and HF, the 5-year survival rate is a mere 12.5%.4

For patients with T2D and no HF, the 5-year survival rate is greater than 80%.4

Survival Rate for Patients with T2D

*Based on a 4-year analysis of 45,227 patients from the international REACH registry.1

Based on 23,216 hospitalizations for heart failure among patients aged 18-64 from the 2005 MarketScan Commercial Claims and Encounters inpatient data set.3

Data based on 115,803 adults aged ≥65 years in fee-for-service Medicare without a baseline HF diagnosis followed for 5 years from 1994 to 1999; incident HF determined using ICD-9 codes.

§Data based on a study of 46,720 Medicare patients with T2D who developed heart failure from 1994-1999.4

References +

VIDEO: THE EPIDEMIOLOGY AND BURDEN OF HEART FAILURE IN TYPE 2 DIABETES (T2D)

For clinicians, the focus on A1C reduction and cardiovascular risk factors for our patients with T2D may make us less sensitive to the significant risk for heart failure that may develop in these patients.

This video, hosted by Dr. Sunder Mudaliar, a Clinical Professor of Medicine at the University of California San Diego School of Medicine, underscores the significance of heart failure as a potential complication of T2D.

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